MetabolicStimulusCalculator.cpp

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#include "Owen11Parameters.hpp"
#include "MetabolicStimulusCalculator.hpp"

template<unsigned DIM>
MetabolicStimulusCalculator<DIM>::MetabolicStimulusCalculator() : AbstractVesselNetworkCalculator<DIM>(),
        mQRef(Owen11Parameters::mpReferenceFlowRateForMetabolicStimulus->GetValue("MetabolicStimulusCalculator")),
        mKm(Owen11Parameters::mpBasalMetabolicStimulus->GetValue("MetabolicStimulusCalculator")),
        mMaxStimulus(1.e12 * unit::per_second)
{

}

template<unsigned DIM>
MetabolicStimulusCalculator<DIM>::~MetabolicStimulusCalculator()
{

}

template <unsigned DIM>
boost::shared_ptr<MetabolicStimulusCalculator<DIM> > MetabolicStimulusCalculator<DIM>::Create()
{
    MAKE_PTR(MetabolicStimulusCalculator<DIM>, pSelf);
    return pSelf;
}


template<unsigned DIM>
units::quantity<unit::flow_rate> MetabolicStimulusCalculator<DIM>::GetQRef()
{
    return mQRef;
}

template<unsigned DIM>
units::quantity<unit::rate> MetabolicStimulusCalculator<DIM>::GetKm()
{
    return mKm;
}

template<unsigned DIM>
units::quantity<unit::rate> MetabolicStimulusCalculator<DIM>::GetMaxStimulus()
{
    return mMaxStimulus;
}

template<unsigned DIM>
void MetabolicStimulusCalculator<DIM>::SetQRef(units::quantity<unit::flow_rate> qRef)
{
    mQRef = units::fabs(qRef);
}

template<unsigned DIM>
void MetabolicStimulusCalculator<DIM>::SetKm(units::quantity<unit::rate> km)
{
    mKm = units::fabs(km);
}

template<unsigned DIM>
void MetabolicStimulusCalculator<DIM>::SetMaxStimulus(units::quantity<unit::rate> maxStimulus)
{
    mMaxStimulus = units::fabs(maxStimulus);
}

template<unsigned DIM>
void MetabolicStimulusCalculator<DIM>::Calculate()
{
    std::vector<boost::shared_ptr<VesselSegment<DIM> > > segments = this->mpNetwork->GetVesselSegments();
    for (unsigned idx = 0; idx < segments.size(); idx++)
    {
        units::quantity<unit::rate> metabolic_stimulus;
        units::quantity<unit::dimensionless> haematocrit = segments[idx]->GetFlowProperties()->GetHaematocrit();
        units::quantity<unit::flow_rate> flow_rate = units::fabs(segments[idx]->GetFlowProperties()->GetFlowRate());

        if (flow_rate > 0.0 * unit::metre_cubed_per_second)
        {
            if (haematocrit > 0.0)
            {
                metabolic_stimulus = mKm * log10(mQRef / (flow_rate * haematocrit) + 1.0);
            }
            else
            {
                metabolic_stimulus = mKm;
            }
        }
        else
        {
            metabolic_stimulus = 0.0 * unit::per_second;
        }
        segments[idx]->GetFlowProperties()->SetGrowthStimulus(segments[idx]->GetFlowProperties()->GetGrowthStimulus() + metabolic_stimulus);
    }
}

// Explicit instantiation
template class MetabolicStimulusCalculator<2>;
template class MetabolicStimulusCalculator<3>;