Chaste  Build::
MetabolicStimulusCalculator.cpp
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35 
36 #include "Owen11Parameters.hpp"
37 #include "MetabolicStimulusCalculator.hpp"
38 
39 template<unsigned DIM>
41  mQRef(Owen11Parameters::mpReferenceFlowRateForMetabolicStimulus->GetValue("MetabolicStimulusCalculator")),
42  mKm(Owen11Parameters::mpBasalMetabolicStimulus->GetValue("MetabolicStimulusCalculator")),
43  mMaxStimulus(1.e12 * unit::per_second)
44 {
45 
46 }
47 
48 template<unsigned DIM>
50 {
51 
52 }
53 
54 template <unsigned DIM>
55 boost::shared_ptr<MetabolicStimulusCalculator<DIM> > MetabolicStimulusCalculator<DIM>::Create()
56 {
57  MAKE_PTR(MetabolicStimulusCalculator<DIM>, pSelf);
58  return pSelf;
59 }
60 
61 
62 template<unsigned DIM>
63 units::quantity<unit::flow_rate> MetabolicStimulusCalculator<DIM>::GetQRef()
64 {
65  return mQRef;
66 }
67 
68 template<unsigned DIM>
69 units::quantity<unit::rate> MetabolicStimulusCalculator<DIM>::GetKm()
70 {
71  return mKm;
72 }
73 
74 template<unsigned DIM>
76 {
77  return mMaxStimulus;
78 }
79 
80 template<unsigned DIM>
81 void MetabolicStimulusCalculator<DIM>::SetQRef(units::quantity<unit::flow_rate> qRef)
82 {
83  mQRef = units::fabs(qRef);
84 }
85 
86 template<unsigned DIM>
87 void MetabolicStimulusCalculator<DIM>::SetKm(units::quantity<unit::rate> km)
88 {
89  mKm = units::fabs(km);
90 }
91 
92 template<unsigned DIM>
93 void MetabolicStimulusCalculator<DIM>::SetMaxStimulus(units::quantity<unit::rate> maxStimulus)
94 {
95  mMaxStimulus = units::fabs(maxStimulus);
96 }
97 
98 template<unsigned DIM>
100 {
101  std::vector<boost::shared_ptr<VesselSegment<DIM> > > segments = this->mpNetwork->GetVesselSegments();
102  for (unsigned idx = 0; idx < segments.size(); idx++)
103  {
104  units::quantity<unit::rate> metabolic_stimulus;
105  units::quantity<unit::dimensionless> haematocrit = segments[idx]->GetFlowProperties()->GetHaematocrit();
106  units::quantity<unit::flow_rate> flow_rate = units::fabs(segments[idx]->GetFlowProperties()->GetFlowRate());
107 
108  if (flow_rate > 0.0 * unit::metre_cubed_per_second)
109  {
110  if (haematocrit > 0.0)
111  {
112  metabolic_stimulus = mKm * log10(mQRef / (flow_rate * haematocrit) + 1.0);
113  }
114  else
115  {
116  metabolic_stimulus = mKm;
117  }
118  }
119  else
120  {
121  metabolic_stimulus = 0.0 * unit::per_second;
122  }
123  segments[idx]->GetFlowProperties()->SetGrowthStimulus(segments[idx]->GetFlowProperties()->GetGrowthStimulus() + metabolic_stimulus);
124  }
125 }
126 
127 // Explicit instantiation
128 template class MetabolicStimulusCalculator<2>;
129 template class MetabolicStimulusCalculator<3>;
units::quantity< unit::rate > GetMaxStimulus()
void SetKm(units::quantity< unit::rate > km)
void SetQRef(units::quantity< unit::flow_rate > qRef)
boost::shared_ptr< VesselNetwork< DIM > > mpNetwork
units::quantity< unit::rate > mMaxStimulus
units::quantity< unit::rate > GetKm()
units::quantity< unit::flow_rate > GetQRef()
units::quantity< unit::flow_rate > mQRef
units::quantity< unit::rate > mKm
static boost::shared_ptr< MetabolicStimulusCalculator< DIM > > Create()
void SetMaxStimulus(units::quantity< unit::rate > maxStimulus)