#include <Owen11CaUpdateRule.hpp>

Inheritance diagram for Owen11CaUpdateRule< DIM >:

Collaboration diagram for Owen11CaUpdateRule< DIM >:

Public Member Functions
	Owen11CaUpdateRule ()

	~Owen11CaUpdateRule ()

double	EvaluateProbability (unsigned currentNodeIndex, unsigned targetNodeIndex, CaBasedCellPopulation< DIM > &rCellPopulation, double dt, double deltaX, CellPtr cell)

units::quantity< unit::diffusivity >	GetDiffusionParameter ()

void	SetVesselNetwork (boost::shared_ptr< VesselNetwork< DIM > > pVesselNetwork)

void	SetRegularGrid (boost::shared_ptr< RegularGrid< DIM > > pRegularGrid)

void	SetReferenceLengthScale (units::quantity< unit::length > referenceLengthScale)

void	SetDiffusionParameter (units::quantity< unit::diffusivity > diffusionParameter)

void	OutputUpdateRuleParameters (out_stream &rParamsFile)

template<>
double	EvaluateProbability (unsigned currentNodeIndex, unsigned targetNodeIndex, CaBasedCellPopulation< 1 > &rCellPopulation, double dt, double deltaX, CellPtr pCell)

Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)

Private Attributes
units::quantity< unit::diffusivity >	mDiffusionParameter

boost::shared_ptr< VesselNetwork< DIM > >	mpVesselNetwork

boost::shared_ptr< RegularGrid< DIM > >	mpRegularGrid

units::quantity< unit::length >	mReferenceLengthScale

unsigned	mCancerCellCarryingCapacity

Friends
class	TestCaUpdateRules

class	boost::serialization::access

Detailed Description

template<unsigned DIM>
class Owen11CaUpdateRule< DIM >

A diffusion update rule based loosely on Owen et al. 2001. Vessels are treated differently to the paper, as they have their own sprouting and migration rules. However they can occupy space.

The probability of moving to an adjacent lattice site is

D*delta_t*((Nm-N)Nm)/(2*delta_xy)

Where D is the mDiffusionParameter. delta_t is the timestep. delta_xy is the separation of the two lattice sites. Nm is the carrying capacity for the cell type N is the number of cells at the lattice site

In this manifestation only cancer cells diffuse.

Definition at line 65 of file Owen11CaUpdateRule.hpp.

Constructor & Destructor Documentation

template<unsigned DIM>

Owen11CaUpdateRule< DIM >::Owen11CaUpdateRule ( )

Constructor.

Definition at line 43 of file Owen11CaUpdateRule.cpp.

Referenced by Owen11CaUpdateRule< DIM >::serialize().

template<unsigned DIM>

Owen11CaUpdateRule< DIM >::~Owen11CaUpdateRule ( )

Destructor.

Definition at line 55 of file Owen11CaUpdateRule.cpp.

Referenced by Owen11CaUpdateRule< DIM >::serialize().

Member Function Documentation

template<>

double Owen11CaUpdateRule< 1 >::EvaluateProbability	(	unsigned	currentNodeIndex,
		unsigned	targetNodeIndex,
		CaBasedCellPopulation< 1 > &	rCellPopulation,
		double	dt,
		double	deltaX,
		CellPtr	pCell
	)

Specialization to allow used with 1D classes

Parameters

currentNodeIndex	the current index
targetNodeIndex	the target index
rCellPopulation	the cell population
dt	the time increment
deltaX	the grid spacing
pCell	the cell

Returns: the movement probability

Definition at line 113 of file Owen11CaUpdateRule.cpp.

template<unsigned DIM>

double Owen11CaUpdateRule< DIM >::EvaluateProbability	(	unsigned	currentNodeIndex,
		unsigned	targetNodeIndex,
		CaBasedCellPopulation< DIM > &	rCellPopulation,
		double	dt,
		double	deltaX,
		CellPtr	cell
	)

Calculate the probability of a given move.

Uses random diffusion to each neighbouring node, scaled according to distance.

Parameters

currentNodeIndex	The index of the current node/lattice site
targetNodeIndex	The index of the target node/lattice site
rCellPopulation	The cell population
dt	is the time interval
deltaX	defines the size of the lattice site
cell	a pointer to the cell (needed if more than one cell per lattice site