#include <Owen2011OxygenBasedCellCycleModel.hpp>

Inheritance diagram for Owen2011OxygenBasedCellCycleModel:

Collaboration diagram for Owen2011OxygenBasedCellCycleModel:

Public Member Functions
	Owen2011OxygenBasedCellCycleModel (boost::shared_ptr< AbstractCellCycleModelOdeSolver > pOdeSolver=boost::shared_ptr< AbstractCellCycleModelOdeSolver >())

AbstractCellCycleModel *	CreateCellCycleModel ()

void	CheckAndLabelCell ()

units::quantity< unit::time >	GetCurrentQuiescentDuration ()

units::quantity< unit::time >	GetCurrentQuiescenceOnsetTime ()

units::quantity< unit::pressure >	GetEnterQuiescenceOxygenConcentration ()

units::quantity< unit::time >	GetCriticalQuiescentDuration ()

double	GetSDuration () const

double	GetG2Duration () const

double	GetMDuration () const

double	GetPhi ()

double	GetVEGF ()

double	GetP53 ()

units::quantity< unit::pressure >	GetLeaveQuiescenceOxygenConcentration ()

void	Initialise ()

void	InitialiseDaughterCell ()

virtual void	OutputCellCycleModelParameters (out_stream &rParamsFile)

bool	ReadyToDivide ()

virtual void	ResetForDivision ()

void	SetMaxRandInitialPhase (units::quantity< unit::dimensionless > rand_max_phase)

void	SetEnterQuiescenceOxygenConcentration (units::quantity< unit::pressure > enterQuiescenceOxygenConcentration)

void	SetLeaveQuiescenceOxygenConcentration (units::quantity< unit::pressure > leaveQuiescenceOxygenConcentration)

void	SetCriticalQuiescentDuration (units::quantity< unit::time > criticalQuiescentDuration)

void	SetCurrentQuiescenceOnsetTime (units::quantity< unit::time > currentQuiescenceOnsetTime)

void	SetG2Onset (units::quantity< unit::dimensionless > value)

void	SetSOnset (units::quantity< unit::dimensionless > value)

void	SetMOnset (units::quantity< unit::dimensionless > value)

void	SetOdeSolverTimeStep (units::quantity< unit::time > timeStep)

void	SetReferenceTimeScale (units::quantity< unit::time > referenceTimeScale)

void	SetReferenceConcentrationScale (units::quantity< unit::concentration > referenceConcentrationScale)

void	SetThresholdFractionOfNormalCellNeighbours (double value)

void	UpdateQuiescentDuration ()

void	UpdateCellCyclePhase ()

Protected Attributes
units::quantity< unit::time >	mOdeIntegrationTimeStep

units::quantity< unit::dimensionless >	sOnset

units::quantity< unit::dimensionless >	g2Onset

units::quantity< unit::dimensionless >	mOnset

units::quantity< unit::time >	mReferenceTimeScale

units::quantity< unit::concentration >	mReferenceConcentrationScale

units::quantity< unit::solubility >	mReferenceSolubility

units::quantity< unit::dimensionless >	mMaxRandInitialPhase

units::quantity< unit::time >	mCurrentQuiescentDuration

units::quantity< unit::time >	mCurrentQuiescenceOnsetTime

units::quantity< unit::pressure >	mEnterQuiescenceOxygenConcentration

units::quantity< unit::pressure >	mLeaveQuiescenceOxygenConcentration

units::quantity< unit::time >	mCriticalQuiescentDuration

units::quantity< unit::dimensionless >	mp53ThresholdForApoptosisOfNormalCellsInHealthyMicroenvironment

units::quantity< unit::dimensionless >	mp53ThresholdForApoptosisOfNormalCellsInTumourMicroenvironment

units::quantity< unit::dimensionless >	mthresholdFractionOfNormalCellNeighbours

Private Member Functions
template<class Archive >
void	serialize (Archive &archive, const unsigned int version)

void	AdjustOdeParameters (double currentTime)

Friends
class	boost::serialization::access

Detailed Description

Oxygen-dependent ODE-based cell-cycle model. Published by Owen et al. 2011

Definition at line 51 of file Owen2011OxygenBasedCellCycleModel.hpp.

Constructor & Destructor Documentation

Owen2011OxygenBasedCellCycleModel::Owen2011OxygenBasedCellCycleModel ( boost::shared_ptr< AbstractCellCycleModelOdeSolver > pOdeSolver = boost::shared_ptr<AbstractCellCycleModelOdeSolver>() )

Default constructor.

Parameters

pOdeSolver An optional pointer to a cell-cycle model ODE solver object (allows the use of different ODE solvers)

Definition at line 56 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mOdeIntegrationTimeStep, GenericParameters::mpGasConcentrationAtStp, Secomb04Parameters::mpOxygenVolumetricSolubility, mReferenceSolubility, and mReferenceTimeScale.

Referenced by CreateCellCycleModel().

Member Function Documentation

void Owen2011OxygenBasedCellCycleModel::AdjustOdeParameters ( double currentTime )

private

Adjust any ODE parameters needed before solving until currentTime.

Parameters

currentTime the time up to which the system will be solved.

Definition at line 87 of file Owen2011OxygenBasedCellCycleModel.cpp.

Referenced by serialize().

void Owen2011OxygenBasedCellCycleModel::CheckAndLabelCell ( )

Check if the oxygen concentration of the cell is below the EnterQuiescenceOxygenConcentration. If it is true the label cells.

Definition at line 96 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCurrentQuiescenceOnsetTime, mEnterQuiescenceOxygenConcentration, mp53ThresholdForApoptosisOfNormalCellsInHealthyMicroenvironment, mp53ThresholdForApoptosisOfNormalCellsInTumourMicroenvironment, mReferenceConcentrationScale, mReferenceSolubility, mReferenceTimeScale, and mthresholdFractionOfNormalCellNeighbours.

Referenced by UpdateCellCyclePhase().

AbstractCellCycleModel * Owen2011OxygenBasedCellCycleModel::CreateCellCycleModel ( )

Overridden builder method to create new copies of this cell-cycle model.

Returns: a cell cycle model

Definition at line 136 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCriticalQuiescentDuration, mCurrentQuiescenceOnsetTime, mEnterQuiescenceOxygenConcentration, mLeaveQuiescenceOxygenConcentration, mReferenceConcentrationScale, mReferenceTimeScale, Owen2011OxygenBasedCellCycleModel(), SetCriticalQuiescentDuration(), SetCurrentQuiescenceOnsetTime(), SetEnterQuiescenceOxygenConcentration(), SetLeaveQuiescenceOxygenConcentration(), SetReferenceConcentrationScale(), and SetReferenceTimeScale().

units::quantity< unit::time > Owen2011OxygenBasedCellCycleModel::GetCriticalQuiescentDuration ( )

Returns: mCriticalQuiescentDuration

Definition at line 237 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCriticalQuiescentDuration.

units::quantity< unit::time > Owen2011OxygenBasedCellCycleModel::GetCurrentQuiescenceOnsetTime ( )

Returns: mCurrentQuiescenceOnsetTime

Definition at line 222 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCurrentQuiescenceOnsetTime.

units::quantity< unit::time > Owen2011OxygenBasedCellCycleModel::GetCurrentQuiescentDuration ( )

Returns: mCurrentQuiescentDuration

Definition at line 217 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCurrentQuiescentDuration.

units::quantity< unit::pressure > Owen2011OxygenBasedCellCycleModel::GetEnterQuiescenceOxygenConcentration ( )

Returns: mEnterQuiescenceOxygenConcentration

Definition at line 227 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mEnterQuiescenceOxygenConcentration.

double Owen2011OxygenBasedCellCycleModel::GetG2Duration ( ) const

Get the duration of the cell's G2 phase.

Returns: the duration of the cell's G2 phase.

Definition at line 186 of file Owen2011OxygenBasedCellCycleModel.cpp.

units::quantity< unit::pressure > Owen2011OxygenBasedCellCycleModel::GetLeaveQuiescenceOxygenConcentration ( )

Returns: mLeaveQuiescenceOxygenConcentration

Definition at line 232 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mLeaveQuiescenceOxygenConcentration.

double Owen2011OxygenBasedCellCycleModel::GetMDuration ( ) const

Get the duration of the cell's M phase.

Returns: the duration of the cell's M phase.

Definition at line 191 of file Owen2011OxygenBasedCellCycleModel.cpp.

double Owen2011OxygenBasedCellCycleModel::GetP53 ( )

Get the value of p53.

Returns: the value of p53.

Definition at line 210 of file Owen2011OxygenBasedCellCycleModel.cpp.

Referenced by Owen2011TrackingModifier< DIM >::UpdateCellData().

double Owen2011OxygenBasedCellCycleModel::GetPhi ( )

Get the value of phi.

Returns: the value of phi.

Definition at line 196 of file Owen2011OxygenBasedCellCycleModel.cpp.

Referenced by Owen2011TrackingModifier< DIM >::UpdateCellData().

double Owen2011OxygenBasedCellCycleModel::GetSDuration ( ) const

Get the duration of the cell's S phase.

Returns: the duration of the cell's S phase.

Definition at line 181 of file Owen2011OxygenBasedCellCycleModel.cpp.

double Owen2011OxygenBasedCellCycleModel::GetVEGF ( )

Get the value of VEGF.

Returns: the value of VEGF.

Definition at line 203 of file Owen2011OxygenBasedCellCycleModel.cpp.

Referenced by Owen2011TrackingModifier< DIM >::UpdateCellData().

void Owen2011OxygenBasedCellCycleModel::Initialise ( )

Initialise the cell-cycle model at the start of a simulation.

This method will be called precisely once per cell set up in the initial cell population. It is not called on cell division; use ResetForDivision(), CreateCellCycleModel() and InitialiseDaughterCell() for that.

By the time this is called, a CellPopulation will have been set up, so the model can know where its cell is located in space. If relevant to the simulation, any singletons will also have been initialised.

Definition at line 242 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mMaxRandInitialPhase, and mReferenceConcentrationScale.

void Owen2011OxygenBasedCellCycleModel::InitialiseDaughterCell ( )

Overridden InitialiseDaughterCell() method.

Definition at line 258 of file Owen2011OxygenBasedCellCycleModel.cpp.

void Owen2011OxygenBasedCellCycleModel::OutputCellCycleModelParameters ( out_stream & rParamsFile )

virtual

Outputs cell cycle model parameters to files.

Parameters

rParamsFile the file stream to which the parameters are output

Definition at line 264 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCriticalQuiescentDuration, mEnterQuiescenceOxygenConcentration, and mLeaveQuiescenceOxygenConcentration.

bool Owen2011OxygenBasedCellCycleModel::ReadyToDivide ( )

Returns: whether the cell is ready to divide (enter M phase).

The intention is that this method is called precisely once at each timestep of the simulation. However this does not appear to always be the case at present, and so it can cope with more unusual usage patterns.

Definition at line 292 of file Owen2011OxygenBasedCellCycleModel.cpp.

References UpdateCellCyclePhase().

void Owen2011OxygenBasedCellCycleModel::ResetForDivision ( )

virtual

Resets the oxygen-based model to the start of the cell cycle (this model does not cycle naturally). Cells are given a new birth time and cell cycle proteins are reset. Note that the oxygen concentration maintains its current value.

Should only be called by the Cell Divide() method.

Definition at line 274 of file Owen2011OxygenBasedCellCycleModel.cpp.

Referenced by UpdateCellCyclePhase().

template<class Archive >

void Owen2011OxygenBasedCellCycleModel::serialize	(	Archive &	archive,
		const unsigned int	version
	)

inlineprivate

Archive the cell-cycle model and ODE system.

Parameters

archive	the archive
version	the archive version

Definition at line 65 of file Owen2011OxygenBasedCellCycleModel.hpp.

References AdjustOdeParameters(), mCriticalQuiescentDuration, mCurrentQuiescenceOnsetTime, mCurrentQuiescentDuration, mEnterQuiescenceOxygenConcentration, and mLeaveQuiescenceOxygenConcentration.

void Owen2011OxygenBasedCellCycleModel::SetCriticalQuiescentDuration ( units::quantity< unit::time > criticalQuiescentDuration )

Set method for mCriticalQuiescentDuration.

Parameters

criticalQuiescentDuration the new value of mCriticalQuiescentDuration

Definition at line 369 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCriticalQuiescentDuration.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetCurrentQuiescenceOnsetTime ( units::quantity< unit::time > currentQuiescenceOnsetTime )

Set method for mCurrentQuiescenceOnsetTime.

Parameters

currentQuiescenceOnsetTime the new value of mCurrentQuiescenceOnsetTime

Definition at line 375 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCurrentQuiescenceOnsetTime.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetEnterQuiescenceOxygenConcentration ( units::quantity< unit::pressure > enterQuiescenceOxygenConcentration )

Set method for mEnterQuiescenceOxygenConcentration.

Parameters

enterQuiescenceOxygenConcentration the new value of mEnterQuiescenceOxygenConcentration

Definition at line 357 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mEnterQuiescenceOxygenConcentration.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetG2Onset ( units::quantity< unit::dimensionless > value )

Set the G2 onset time

Parameters

value the G2 onset time

Definition at line 325 of file Owen2011OxygenBasedCellCycleModel.cpp.

References g2Onset.

void Owen2011OxygenBasedCellCycleModel::SetLeaveQuiescenceOxygenConcentration ( units::quantity< unit::pressure > leaveQuiescenceOxygenConcentration )

Set method for mLeaveQuiescenceOxygenConcentration.

Parameters

leaveQuiescenceOxygenConcentration the new value of mLeaveQuiescenceOxygenConcentration

Definition at line 363 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mLeaveQuiescenceOxygenConcentration.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetMaxRandInitialPhase ( units::quantity< unit::dimensionless > rand_max_phase )

Set maximum phase of cell upon initialisation.

Parameters

rand_max_phase the maximum phase value at initialization

Definition at line 351 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mMaxRandInitialPhase.

void Owen2011OxygenBasedCellCycleModel::SetMOnset ( units::quantity< unit::dimensionless > value )

Set the M onset time

Parameters

value the M onset time

Definition at line 330 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mOnset.

void Owen2011OxygenBasedCellCycleModel::SetOdeSolverTimeStep ( units::quantity< unit::time > timeStep )

Set the ODE solver time step

Parameters

timeStep the ODE solver time step

Definition at line 335 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mOdeIntegrationTimeStep, and mReferenceTimeScale.

void Owen2011OxygenBasedCellCycleModel::SetReferenceConcentrationScale ( units::quantity< unit::concentration > referenceConcentrationScale )

Set the reference concentration scale

Parameters

referenceConcentrationScale the reference concentration scale

Definition at line 346 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mReferenceConcentrationScale.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetReferenceTimeScale ( units::quantity< unit::time > referenceTimeScale )

Set the reference timescale

Parameters

referenceTimeScale the reference timescale

Definition at line 341 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mReferenceTimeScale.

Referenced by CreateCellCycleModel().

void Owen2011OxygenBasedCellCycleModel::SetSOnset ( units::quantity< unit::dimensionless > value )

Set the S2 onset time

Parameters

value the S2 onset time

Definition at line 320 of file Owen2011OxygenBasedCellCycleModel.cpp.

References sOnset.

void Owen2011OxygenBasedCellCycleModel::SetThresholdFractionOfNormalCellNeighbours ( double value )

Set method for mthresholdFractionOfNormalCellNeighbours.

Parameters

value the new value of mthresholdFractionOfNormalCellNeighbours

Definition at line 381 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mthresholdFractionOfNormalCellNeighbours.

void Owen2011OxygenBasedCellCycleModel::UpdateCellCyclePhase ( )

Update cell-cycle phase.

Definition at line 386 of file Owen2011OxygenBasedCellCycleModel.cpp.

References CheckAndLabelCell(), g2Onset, mOnset, ResetForDivision(), sOnset, and UpdateQuiescentDuration().

Referenced by ReadyToDivide().

void Owen2011OxygenBasedCellCycleModel::UpdateQuiescentDuration ( )

Update the duration for which the cell has been quiescent.

Definition at line 449 of file Owen2011OxygenBasedCellCycleModel.cpp.

References mCriticalQuiescentDuration, mCurrentQuiescenceOnsetTime, mCurrentQuiescentDuration, mLeaveQuiescenceOxygenConcentration, mReferenceConcentrationScale, mReferenceSolubility, and mReferenceTimeScale.

Referenced by UpdateCellCyclePhase().

Friends And Related Function Documentation

friend class boost::serialization::access

friend

Needed for serialization.

Definition at line 57 of file Owen2011OxygenBasedCellCycleModel.hpp.

Member Data Documentation

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::g2Onset

protected

Cell cycle fraction at which G2 phase begins

Definition at line 97 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by SetG2Onset(), and UpdateCellCyclePhase().

units::quantity<unit::time> Owen2011OxygenBasedCellCycleModel::mCriticalQuiescentDuration

protected

Critical quiescent duration.

Definition at line 148 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CreateCellCycleModel(), GetCriticalQuiescentDuration(), OutputCellCycleModelParameters(), serialize(), SetCriticalQuiescentDuration(), and UpdateQuiescentDuration().

units::quantity<unit::time> Owen2011OxygenBasedCellCycleModel::mCurrentQuiescenceOnsetTime

protected

The time when the current period of quiescence began.

Definition at line 132 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), CreateCellCycleModel(), GetCurrentQuiescenceOnsetTime(), serialize(), SetCurrentQuiescenceOnsetTime(), and UpdateQuiescentDuration().

units::quantity<unit::time> Owen2011OxygenBasedCellCycleModel::mCurrentQuiescentDuration

protected

How long the current period of quiescence has lasted.

Definition at line 127 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by GetCurrentQuiescentDuration(), serialize(), and UpdateQuiescentDuration().

units::quantity<unit::pressure> Owen2011OxygenBasedCellCycleModel::mEnterQuiescenceOxygenConcentration

protected

Oxygen concentration below which cancerous cells enter quiescence. A prolonged period of quiescence causes the cell to become apoptotic.

Definition at line 138 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), CreateCellCycleModel(), GetEnterQuiescenceOxygenConcentration(), OutputCellCycleModelParameters(), serialize(), and SetEnterQuiescenceOxygenConcentration().

units::quantity<unit::pressure> Owen2011OxygenBasedCellCycleModel::mLeaveQuiescenceOxygenConcentration

protected

Oxygen concentration above which cancerous cells leave their state of being quiescent

Definition at line 143 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CreateCellCycleModel(), GetLeaveQuiescenceOxygenConcentration(), OutputCellCycleModelParameters(), serialize(), SetLeaveQuiescenceOxygenConcentration(), and UpdateQuiescentDuration().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::mMaxRandInitialPhase

protected

Maximum initial value allocated to phi.

Definition at line 122 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by Initialise(), and SetMaxRandInitialPhase().

units::quantity<unit::time> Owen2011OxygenBasedCellCycleModel::mOdeIntegrationTimeStep

protected

ODE integration time-step

Definition at line 87 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by Owen2011OxygenBasedCellCycleModel(), and SetOdeSolverTimeStep().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::mOnset

protected

Cell cycle fraction at which M phase begins

Definition at line 102 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by SetMOnset(), and UpdateCellCyclePhase().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::mp53ThresholdForApoptosisOfNormalCellsInHealthyMicroenvironment

protected

p53 threshold above which normal cells become apoptotic in a healthy environment.

Definition at line 153 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::mp53ThresholdForApoptosisOfNormalCellsInTumourMicroenvironment

protected

p53 threshold above which normal cells become apoptotic in a tumour environment.

Definition at line 158 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell().

units::quantity<unit::concentration> Owen2011OxygenBasedCellCycleModel::mReferenceConcentrationScale

protected

The reference concentration scale

Definition at line 112 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), CreateCellCycleModel(), Initialise(), SetReferenceConcentrationScale(), and UpdateQuiescentDuration().

units::quantity<unit::solubility> Owen2011OxygenBasedCellCycleModel::mReferenceSolubility

protected

The reference solubility

Definition at line 117 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), Owen2011OxygenBasedCellCycleModel(), and UpdateQuiescentDuration().

units::quantity<unit::time> Owen2011OxygenBasedCellCycleModel::mReferenceTimeScale

protected

The reference time scale

Definition at line 107 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), CreateCellCycleModel(), Owen2011OxygenBasedCellCycleModel(), SetOdeSolverTimeStep(), SetReferenceTimeScale(), and UpdateQuiescentDuration().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::mthresholdFractionOfNormalCellNeighbours

protected

Threshold which defines the proportion of neighbours which must be normal in order for a cell's micro-environment to be considered normal.

Definition at line 164 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by CheckAndLabelCell(), and SetThresholdFractionOfNormalCellNeighbours().

units::quantity<unit::dimensionless> Owen2011OxygenBasedCellCycleModel::sOnset

protected

Cell cycle fraction at which S phase begins

Definition at line 92 of file Owen2011OxygenBasedCellCycleModel.hpp.

Referenced by SetSOnset(), and UpdateCellCyclePhase().

The documentation for this class was generated from the following files:

projects/MicrovesselChaste/src/population/cell/cycle/Owen2011OxygenBasedCellCycleModel.hpp
projects/MicrovesselChaste/src/population/cell/cycle/Owen2011OxygenBasedCellCycleModel.cpp

Public Member Functions

Protected Attributes

Private Member Functions

Friends

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Friends And Related Function Documentation

Member Data Documentation